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5 Powerful Prayers for Anxiety and Depression

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  • Post last modified:May 5, 2025

Prayers to Calm Your Mind and Uplift Your Spirit

Anxiety and depression can be overwhelming, leaving us feeling restless, fearful, and uncertain about the future. If you are struggling with anxious thoughts, constant worry, or feelings of despair, you are not alone. Many people, including those of faith, experience these emotions and wonder how to find peace.

The good news is that prayer can be a powerful way to calm your heart and mind. Turning to God in prayer and surrendering your burdens to Him can bring comfort, strength, and reassurance in difficult times.

Coming to Christ was the best thing that has ever happened to me and turning to prayer brought me more peace than I could have ever thought possible.

In this post, I am going to share some powerful Christian prayers for depression and anxiety. These faith-filled prayers will help you surrender your worries to God, find strength in His presence, and experience the peace that surpasses all understanding.

I hope that these can become your go to on days when you don’t know what or how to pray.

1. The Serenity Prayer – Let Go and Trust God

God, grant me the serenity
to accept the things I cannot change
the courage to change the things I can
and the wisdom to know the difference.

Living one day at a time,
enjoying one moment at a time.
Accepting hardships as the pathway to peace.
Taking, as he did, the sinful world as it is,
not as I would have it.
Trusting that He will make all things right
if I surrender to His will;
that I may be reasonably happy in this life,
and supremely happy with Him forever.

Amen.

This well-known prayer is a reminder to trust God with what is beyond our control. It encourages us to seek peace in acceptance, courage to act when needed, and wisdom to discern the difference. If you are feeling anxious or overwhelmed, take a moment to pray these words and release your worries to God.

2. Prayer of St. Thomas Aquinas – Draw Closer to God

Grant me, O Lord my God,
a mind to know you,
a heart to seek you,
wisdom to find you,
conduct pleasing to you,
faithful perseverance in waiting for you,
and a hope of finally embracing you.

Amen.

This prayer by Thomas Aquinas asks for what’s important. When we seek God first, peace will follow. Remember that in Christ Jesus we have everything we need.

3. Peace Prayer – Shift Your Focus

Lord, make me an instrument of your peace:
where there is hatred, let me sow love;
where there is injury, pardon;
where there is doubt, faith;
where there is despair, hope;
where there is darkness, light;
where there is sadness, joy.

O divine Master, grant that I may not so much seek
to be consoled as to console,
to be understood as to understand,
to be loved as to love.
For it is in giving that we receive,
it is in pardoning that we are pardoned,
and it is in dying that we are born to eternal life.

Amen

This prayer shifts our focus from ourselves to others. In my experience, apathy leads to anxiety and deepens depression. I love this prayer because it reminds us that by being a light for others, we will be able to see the light ourselves.

4. Psalm 23 – Find Comfort in God’s Presence

The Lord is my shepherd, I lack nothing.
    He makes me lie down in green pastures,
he leads me beside quiet waters,
    he refreshes my soul.
He guides me along the right paths
    for his name’s sake.
Even though I walk
    through the darkest valley,
I will fear no evil,
    for you are with me;
your rod and your staff,
    they comfort me.

You prepare a table before me
    in the presence of my enemies.
You anoint my head with oil;
    my cup overflows.
Surely your goodness and love will follow me
    all the days of my life,
and I will dwell in the house of the Lord
    forever.

Amen

This one is straight from the Bible, so you know it’s good! It’s a deeply comforting passage that reminds us of God’s protection and guidance. Psalm 23 is perfect for those who are feeling lost or overwhelmed. I find myself coming back to this one again and again.

5. A Prayer of Gratitude – Trade Worry for Thankfulness

Heavenly Father, I come before you today with a heart full of gratitude. Thank you for your countless blessings and your unwavering love. Thank you for the gift of life, for the air I breathe, and for the strength you give me each day. Your grace and mercy sustain me, and I am deeply grateful for your presence in my life.

Thank you for my family, friends, and the community you have surrounded me with. Thank you for providing for my needs and for guiding me with your wisdom. Even in times of trial, I thank you for the lessons and the growth that come from trusting in you.

Lord, may I never take your blessings for granted. Help me to remain mindful of your goodness and to share your love and kindness with others. I praise your name and give thanks for all that you are and all that you do.

In Jesus’ name, I pray. Amen.

Gratitude is a powerful way to overcome anxiety and depression. Sometimes just shifting our focus from everything that is going wrong to all the things we have in life, can make all the difference. After all, the mind cannot be anxious and grateful at the same time.

Final Thoughts

If you are struggling with anxiety or depression, remember that prayer is a powerful way to find comfort and strength. God is always listening, and He cares deeply about your burdens. Whenever you feel overwhelmed, turn to these short prayers to help ease your worries and find peace in His presence.

Do you have a favorite prayer that brings you comfort in times of anxiety? Share it in the comments below!

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